Study finds AstraZeneca’s COVID-19 vaccine follows genetic instructions

Study finds AstraZeneca’s COVID-19 vaccine follows genetic instructions
The offices of British-Swedish multinational pharmaceutical and biopharmaceutical company AstraZeneca PLC in Macclesfield, Cheshire, UK, July 21, 2020. (AFP)
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Updated 22 October 2020

Study finds AstraZeneca’s COVID-19 vaccine follows genetic instructions

Study finds AstraZeneca’s COVID-19 vaccine follows genetic instructions
  • Bristol University virology expert David Matthews: The vaccine is doing everything we expected and that is only good news in our fight against the illness
  • AstraZeneca, which is developing the vaccine with Oxford University researchers, is seen as a frontrunner in the race to produce a vaccine to protect against COVID-19

LONDON: AstraZeneca’s Oxford COVID-19 vaccine accurately follows the genetic instructions programmed into it by its developers to successfully provoke a strong immune response, according to a detailed analysis carried out by independent UK scientists.
“The vaccine is doing everything we expected and that is only good news in our fight against the illness,” said David Matthews, an expert in virology from Bristol University, who led the research.
AstraZeneca, which is developing the vaccine with Oxford University researchers, is seen as a frontrunner in the race to produce a vaccine to protect against COVID-19.
The first data from late-stage large-scale clinical trials being conducted in several countries around the world, including Brazil, the United States and Britain, are expected to be released before the end of the year.
The vaccine — known either as ChAdOx1 or AZD1222 — is made by taking a common cold virus called an adenovirus from chimpanzees and deleting about 20% of the virus’s instructions. This means it is impossible for the vaccine to replicate or cause disease in humans.
The Bristol researchers’ focus was to assess how often and how accurately the vaccine is copying and using the genetic instructions programmed into it by its designers. These instructions detail how to make the spike protein from the coronavirus, SARS-CoV-2 that causes COVID-19.
Once the spike protein is made, the immune system reacts to it, training the immune system to identify a real COVID-19 infection.
“This is an important study as we are able to confirm that the genetic instructions underpinning this vaccine ... are correctly followed when they get into a human cell,” Matthews said in a statement about the work.
His team’s research was not peer reviewed by other scientists, but was published as a preprint before review.


Moscow starts mass COVID-19 vaccination with its Sputnik V shot

Updated 35 min 15 sec ago

Moscow starts mass COVID-19 vaccination with its Sputnik V shot

Moscow starts mass COVID-19 vaccination with its Sputnik V shot
  • The task force said the Russian-made vaccine would first be made available to doctors and other medical workers, teachers and social workers
  • Moscow, the epicenter of Russia’s coronavirus outbreak, registered 7,993 new cases overnight

MOSCOW: Moscow began distributing the Sputnik V COVID-19 shot via 70 clinics on Saturday, marking Russia’s first mass vaccination against the disease, the city’s coronavirus task force said.
The task force said the Russian-made vaccine would first be made available to doctors and other medical workers, teachers and social workers because they ran the highest risk of exposure to the disease.
“You are working at an educational institution and have top-priority for the COVID-19 vaccine, free of charge,” read a phone text message received by one Muscovite, an elementary school teacher, early on Saturday and seen by Reuters.
Moscow, the epicenter of Russia’s coronavirus outbreak, registered 7,993 new cases overnight, up from 6,868 a day before and well above the daily tallies of around 700 seen in early September.
“Over the first five hours, 5,000 people signed up for the jab — teachers, doctors, social workers, those who are today risking their health and lives the most,” Mayor Sergei Sobyanin wrote on his personal website on Friday.
The age for those receiving shots is capped at 60. People with certain underlying health conditions, pregnant women and those who have had a respiratory illness for the past two weeks are barred from vaccination.
Russia has developed two COVID-19 vaccines, Sputnik V which is backed by the Russian Direct Investment Fund and another developed by Siberia’s Vector Institute, with final trials for the both yet to be completed.
Scientists have raised concerns about the speed at which Russia has worked, giving the regulatory go-ahead for its vaccines and launching mass vaccinations before full trials to test its safety and efficacy had been completed.
The Sputnik V vaccine is administered in two injections, with the second dose is expected to be given 21 days after the first.
Moscow closed down all public places including parks and cafes, with exception for delivery, in late March, with police patrolling the streets looking for whose violating the rules. Restrictions were eased from mid-June, however.
Russia as a whole reported 28,782 new infections on Saturday, its highest daily tally, pushing the national total to 2,431,731, the fourth-highest in the world.
In October, certain restrictions such as remote learning for some secondary school children and a 30% limit on the number of workers allowed in offices were introduced again.